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New formulation metered dose inhaler increases breath alcohol levels
1Department of Child Health, University of Leicester, U.K.
Respiratory Medicine
|August 28, 1999
Summary
New inhalers containing salbutamol and ethanol can temporarily increase breath alcohol levels. Measurements should be delayed for 2 minutes after use, especially with poor inhalation technique, to ensure accuracy.
Area of Science:
- Pharmacology
- Respiratory Medicine
- Analytical Chemistry
Background:
- A novel chlorofluorocarbon-free metered dose inhaler (MDI) utilizing salbutamol with ethanol as a co-solvent is now available.
- Ethanol content in MDIs may impact breath alcohol measurements.
Purpose of the Study:
- To assess the impact of the new salbutamol MDI on breath alcohol concentration.
- To determine the duration of elevated breath alcohol levels post-inhalation.
Main Methods:
- 10 healthy volunteers participated in the study.
- Breath alcohol levels were measured after two inhalations using the new MDI.
- Inhalation techniques (good vs. poor) and the use of a spacer device were evaluated.
Main Results:
- Breath alcohol levels increased significantly after MDI use, reaching 35 micrograms/100 ml breath (UK driving limit) with poor technique.
- A spacer device reduced breath alcohol levels.
- Levels returned to near zero within 2 minutes in all participants.
Conclusions:
- The new salbutamol MDI can cause transient elevations in breath alcohol.
- Breath alcohol testing should be deferred for at least 2 minutes after using this MDI.
- Proper inhalation technique and spacer use may mitigate the effect.