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Origin and evolution of binucleate cells in cultures of HEp-2 cells
A Serrano1, V Rodilla, J A Pellicer
1Departament de Biologia Animal, Universitat de València, Spain.
Cell Proliferation
|February 1, 1994
Abstract:
The origin and evolution of binucleate cells in cultures of HEp-2 cells have been studied by means of interval photography and time-lapse video-recording. Binucleate cells most frequently formed by the fusion of two sister cells born in a previous mitosis. The study of binucleate cells has shown that they are a cellular type able to successfully undergo mitosis. However, the mitosis may be bipolar, tripolar or multipolar. The daughter cells arising from these divisions do not follow a clear pattern in the number of nuclei they have, instead showing a wide range of possibilities.