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Updated: Aug 12, 2026
12:08
Ex Vivo Infection of Live Tissue with Oncolytic Viruses
Published on: June 25, 2011
DNA viruses and oncogenesis
1Department of Medicine, University of Miami School of Medicine, FL 33101, USA.
Critical Reviews in Oncogenesis
|September 1, 1999
Abstract:
This review addresses the biology and role of DNA viruses in oncogenesis.
Insights
This review explores the biology and function of DNA viruses in cancer development. Understanding these viral mechanisms is key to advancing oncogenesis research and potential therapies.
Area of Science:
- Oncology
- Virology
- Molecular Biology
Background:
- DNA viruses are implicated in a significant proportion of human cancers.
- Understanding the molecular mechanisms by which DNA viruses contribute to cancer is crucial.
Purpose of the Study:
- To review the current knowledge on the biology of DNA viruses.
- To elucidate the role of DNA viruses in the process of oncogenesis.
Main Methods:
- Literature review of peer-reviewed scientific articles.
- Synthesis of information on viral replication, host-pathogen interactions, and oncogenic pathways.
Main Results:
- Identification of key DNA viruses associated with cancer (e.g., HPV, HBV, EBV, SV40).
- Description of common oncogenic mechanisms, including viral oncoprotein activity and disruption of host cell cycle regulation.
Conclusions:
- DNA viruses play a direct and significant role in the oncogenesis of various human cancers.
- Further research into viral oncogenesis can lead to novel diagnostic and therapeutic strategies.
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