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Review Article: Dynamin-Related Protein 1 in Cancer Progression: Mechanisms and Implications
Mankun Wei1, Ying Liu2, Jianxiang Liu2
1Jiangxi Normal University.
Abstract:
Dynamin-related protein 1 (DRP1), a key regulator of mitochondrial fission, plays a pivotal role in cancer progression by modulating diverse oncogenic processes. This review highlights the multifaceted contributions of DRP1 to tumorigenesis, emphasizing its involvement in metabolic reprogramming, metastasis, drug resistance, cancer stem cell (CSC) maintenance, and cell death regulation. DRP1 drives metabolic shifts, such as enhanced glycolysis and fatty acid oxidation, to fuel tumor growth and survival. It promotes metastasis by facilitating epithelial-mesenchymal transition (EMT), mitochondrial dynamics, and oxidative stress regulation. DRP1 also mediates chemoresistance through mitochondrial fission-dependent mechanisms and modulates CSC stemness via asymmetric division and metabolic plasticity. Furthermore, DRP1 influences apoptosis and ferroptosis, making it a potential therapeutic target. Pharmacological inhibition of DRP1 has shown promise in sensitizing tumors to therapy and suppressing CSC populations. This review underscores DRP1 as a critical nexus in cancer biology, with broad implications for developing targeted anticancer strategies.
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