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Human therapeutic cloning
R P Lanza1, J B Cibelli, M D West
1Tissue Engineering and Transplant Medicine, Advanced Cell Technology, One Innovation Drive, Worcester, Massachusetts 01605, USA. rlanza@advancedcell.com
Nature Medicine
|September 2, 1999
Summary
Somatic cell nuclear reprogramming is a routine technique in livestock. This method may soon enable cloning of genetically matched cells and tissues for transplantation in patients with tissue loss or dysfunction.
Area of Science:
- Biotechnology
- Reproductive Biology
- Cellular Medicine
Background:
- Somatic cell nuclear reprogramming is established in livestock.
- Tissue loss and dysfunction affect numerous patients.
Purpose of the Study:
- To discuss the potential clinical applications of somatic cell nuclear reprogramming.
- To explore the use of cloned cells and tissues for regenerative medicine.
Main Methods:
- Review of current somatic cell nuclear reprogramming techniques.
- Discussion of potential future applications in transplantation.
Main Results:
- Somatic cell nuclear reprogramming is a well-established technique in livestock.
- The potential exists for therapeutic cloning to generate patient-specific tissues.
Conclusions:
- Somatic cell nuclear reprogramming techniques are advancing rapidly.
- Therapeutic cloning holds promise for treating disorders involving tissue loss or dysfunction.