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Related Experiment Video

Updated: Jun 19, 2026

Title Cell Encapsulation by Droplets
13:10

Title Cell Encapsulation by Droplets

Published on: October 1, 2007

Encapsulation technologies.

R P Lanza1, W M Kühtreiber, W L Chick

  • 1Biohybrid Technologies Inc., Shrewsbury, Massachusetts 01545.

Tissue Engineering
|November 3, 2009
PubMed
Summary
This summary is machine-generated.

Encapsulation systems using permselective barriers isolate cells, preventing immune rejection and the need for immunosuppressive drugs. This breakthrough offers a viable method for treating diabetes with encapsulated pancreatic islets, improving glucose control.

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Last Updated: Jun 19, 2026

Title Cell Encapsulation by Droplets
13:10

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Published on: October 1, 2007

High Throughput Single-cell and Multiple-cell Micro-encapsulation
16:19

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08:30

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Published on: June 2, 2015

Area of Science:

  • Biomedical Engineering
  • Immunology
  • Endocrinology

Background:

  • Cell encapsulation systems utilize permselective barriers to shield transplanted cells from host immune responses.
  • This approach eliminates the need for chronic, high-dose immunosuppressive drugs, mitigating associated risks.
  • It also addresses challenges in human cell sourcing by enabling the use of animal-derived cells and tissues.

Purpose of the Study:

  • To evaluate the efficacy of three distinct immunoisolation device designs for encapsulating pancreatic islets.
  • To assess the potential of these encapsulated islet systems as a living drug delivery and detoxification therapy, primarily for diabetes.
  • To determine if these systems can prevent immune rejection and restore glucose homeostasis without immunosuppression.

Main Methods:

  • Three types of encapsulation devices were developed: perfusion devices (AV shunts), tubular membrane diffusion chambers, and microreactors.
  • Canine, porcine, and bovine pancreatic islets were encapsulated within permselective acrylic membranes (80 kDa exclusion).
  • Devices were implanted intraperitoneally into various animal models of diabetes (dogs, rats, mice) with and without immunosuppression.

Main Results:

  • All three encapsulation systems demonstrated significant improvements in glucose homeostasis in diabetic animal models.
  • The encapsulated islet systems functioned effectively for extended periods, ranging from months to over a year.
  • Successful islet transplantation was achieved without immunosuppression in several experimental groups.

Conclusions:

  • Encapsulation technology provides a promising strategy for cell-based therapies, particularly for diabetes treatment.
  • Immunoisolation devices offer a viable alternative to traditional immunosuppression, reducing treatment burdens and risks.
  • Further development of these living drug delivery systems holds potential for treating a range of diseases requiring cell transplantation.