Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Drug screening--beyond the bottleneck.

A Dove

    Nature Biotechnology
    |September 3, 1999
    PubMed
    Summary
    This summary is machine-generated.

    High-throughput screening (HTS) shows promise but requires significant advancements to fulfill its potential in drug discovery and biological research.

    Related Experiment Videos

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Association between Cognitive Reserve Indicator and Chronic Disease-Free Survival: A Large Community-Based Longitudinal Study.

    The journal of prevention of Alzheimer's disease·2024
    Same author

    Association between Resting Heart Rate and Machine Learning-Based Brain Age in Middle- and Older-Age.

    The journal of prevention of Alzheimer's disease·2024
    Same author

    Association of Cognitive Reserve Indicator with Cognitive Decline and Structural Brain Differences in Middle and Older Age: Findings from the UK Biobank.

    The journal of prevention of Alzheimer's disease·2024
    Same author

    Axion Dark Matter Experiment: Detailed design and operations.

    The Review of scientific instruments·2022
    Same author

    Extended Search for the Invisible Axion with the Axion Dark Matter Experiment.

    Physical review letters·2020
    Same author

    Spatial distribution and trends of total mercury in waters of the Great Lakes and connecting channels using an improved sampling technique.

    Environmental pollution (Barking, Essex : 1987)·2011

    Area of Science:

    • Pharmacology
    • Biotechnology
    • Drug Discovery

    Background:

    • High-throughput screening (HTS) is a key technology in modern drug discovery.
    • Despite advancements, HTS faces challenges in efficiency and predictive power.

    Purpose of the Study:

    • To evaluate the current state and future potential of high-throughput screening.
    • To identify key areas for improvement in HTS methodologies.

    Main Methods:

    • Review of current HTS technologies and applications.
    • Analysis of limitations and bottlenecks in HTS workflows.

    Main Results:

    • Current HTS methods often fall short of expectations.
    • Significant improvements are needed in assay miniaturization, data analysis, and hit validation.

    Conclusions:

    • High-throughput screening requires further innovation to realize its full potential.
    • Addressing current limitations is crucial for accelerating the discovery of novel therapeutics.