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Induction of cellular immunosuppression by the human papillomavirus type 16 E7 oncogenic protein
H Le Buanec1, A Lachgar, R D'Anna
1Laboratoire de Physiologie Cellulaire, Pierre et Marie Curie University, Paris, France.
Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|September 3, 1999
Abstract:
The human papillomavirus type 16 (HPV-16) E7 oncogenic protein is found in the culture supernatant of SiHa cells, a cervical carcinoma cell line. Extracellular E7 protein, acting as a viral toxin in human immune cells, induces the overproduction of the immune suppressive IFN alpha cytokine by APCs, and inhibits the T-cell response to recall and allogenic antigens. These effects should be taken into account for the design of anti-human cervical carcinoma vaccines.