Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Expression pattern of the Tbr2 (Eomesodermin) gene during mouse and chick brain development.

A Bulfone1, S Martinez, V Marigo

  • 1Telethon Institute of Genetics and Medicine (TIGEM), San Raffaele Biomedical Science Park, Milan, Italy. bulfone@tigem.it

Mechanisms of Development
|September 3, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Human exposure to Dirofilaria immitis following a canine heartworm disease elimination program in Linosa Island (Sicily, Italy).

Acta tropica·2025
Same author

Cross-architecture tuning of silicon and SiGe-based quantum devices using machine learning.

Scientific reports·2024
Same author

Dim artificial light at night alters gene expression rhythms and growth in a key seagrass species (Posidonia oceanica).

Scientific reports·2023
Same author

Validation of a suite of ERP and QEEG biomarkers in a pre-competitive, industry-led study in subjects with schizophrenia and healthy volunteers.

Schizophrenia research·2023
Same author

Nanostructured 3C-SiC on Si by a network of (111) platelets: a fully textured film generated by intrinsic growth anisotropy.

Physical chemistry chemical physics : PCCP·2022
Same author

Microbiome structure in biofilms from a volcanic island in Maritime Antarctica investigated by genome-centric metagenomics and metatranscriptomics.

Microbiological research·2022

Researchers identified Tbr1 and Tbr2 genes in chickens and mice, revealing conserved roles in embryonic brain development. Their expression patterns offer insights into early developmental processes in both species.

Area of Science:

  • Developmental Biology
  • Genetics
  • Neuroscience

Background:

  • T-box genes are crucial for development, characterized by a conserved T-domain.
  • Understanding T-box gene function is key to deciphering developmental processes.

Purpose of the Study:

  • To clone and characterize chicken Tbr1 and murine/chicken Tbr2 genes.
  • To investigate the expression patterns of Tbr1 and Tbr2 during embryogenesis in mice and chicks.
  • To identify conserved developmental roles of these genes.

Main Methods:

  • Gene cloning techniques.
  • Chromosomal mapping of murine Tbr2.
  • Whole-mount in situ hybridization or similar expression analysis techniques.

Main Results:

Related Experiment Videos

  • Cloning of chicken Tbr1 and murine/chicken Tbr2 (orthologs of Xenopus eomesodermin).
  • Murine Tbr2 mapped to chromosome 9.
  • Both Tbr1 and Tbr2 exhibit conserved expression in the telencephalic pallium of mice and chicks.
  • Chick Tbr2 shows dynamic expression during gastrulation.

Conclusions:

  • Tbr1 and Tbr2 play conserved roles in the developing telencephalic pallium across species.
  • Chick Tbr2 has a distinct role in early gastrulation.
  • These findings contribute to understanding T-box gene function in vertebrate development.