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Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model
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Studying Age-dependent Genomic Instability using the S. cerevisiae Chronological Lifespan Model

Published on: September 29, 2011

Effect of Cu,Zn superoxide dismutase disruption mutation on replicative senescence in Saccharomyces cerevisiae

M G Barker1, L J Brimage, K A Smart

  • 1School of Biological and Molecular Sciences, Oxford Brookes University, Headington, UK.

FEMS Microbiology Letters
|September 4, 1999
PubMed

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Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...