Related Experiment Videos
Making drugs out of oligonucleotides: a brief review and perspective
1Isis Pharmaceuticals, Carlsbad, CA 92008, USA.
Abstract:
I provide a brief review and perspective thoughts concerning the antisense oligonucleotide, drug discovery paradigm.
Related Concept Videos
Articles linked to this work by shared authors, journal, and citation graph.
A brief history, status, and perspective of modified oligonucleotides for chemotherapeutic applications.
Current protocols in nucleic acid chemistry·2008
Chimeric RNA with modified backbones: alternating methylene(methylimino) linked phosphodiester backbone oligonucleotides with 2'-OH and 2'-OMe groups.
Nucleosides, nucleotides & nucleic acids·2001
Identification of ligands for RNA targets via structure-based virtual screening: HIV-1 TAR.
Journal of computer-aided molecular design·2000
Synthetic oligonucleotides as therapeutics: the coming of age.
Biotechnology annual review·2000
Site-specific cross-linking of nucleic acids using the abasic site.
Organic letters·2000
PURINE FUNCTIONALIZED CONGENERS AS MOLECULAR PROBES FOR ADENOSINE RECEPTORS.
Nucleosides & nucleotides·2025
Mutation induced by deoxyxanthosine in codon 12 of a synthetic c-Ha-ras gene.
Nucleosides & nucleotides·2018
A SURVEY OF NONXANTHINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS.
Nucleosides & nucleotides·2016
SYNTHESIS AND BIOLOGICAL ACTIVITY OF NOVEL 2-THIO DERIVATIVES OF ATP.
Nucleosides & nucleotides·2014
Stereoselective synthesis of beta-L-2',3'-dideoxy- and L-2',3'-didehydro-2',3'-dideoxy purine nucleosides.
Nucleosides & nucleotides·2000
Introduction of 6-formylcytidine into a Myb binding sequence.
Nucleosides & nucleotides·2000
Structure-guided targeting of Plasmodium falciparum aminopeptidase P: exploiting S4' dimer-interface interactions for selective antimalarial drug design.
Expert opinion on therapeutic targets·2026
The quest to identify the molecular target of lithium.
Physical chemistry chemical physics : PCCP·2026
Design and syntheses of 4-aminoquinoline-thiazolidinone hybrids as anti-protozoal agents.
Frontiers in chemistry·2026
Computational screening of natural product inhibitor stargeting the MDM2-p53 interaction: docking and molecular dynamics insights for retinoblastoma therapy.
American journal of translational research·2026