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Synthesis and biological activity of 2',5'-oligoadenylate trimers containing 5'-terminal 5'-amino-5'-deoxy- and
E I Kvasyuk1, I A Mikhailopulo, R J Suhadolnik
1Institute of Bioorganic Chemistry, Byelorussian Academy of Sciences, Minsk, Belarus.
Nucleosides & Nucleotides
|September 4, 1999
Abstract:
Some new 2',5'-oligonucleotide trimers containing 5'-terminal 5'-amino-5'-deoxy- and 5'-amino-3',5'-dideoxyadenosine derivatives have been synthesized. Some of the trimers showed biological inhibitions of HIV-1 reverse transcriptase (RT), HIV-1 induced syncytia formation and PCR amplification.