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Relative effects of graft copolymer and polyamines on triplex stabilization under physiological conditions
A Ferdous1, H Watanabe, T Akaike
1Department of Biomolecular Engineering, Tokyo Institute of Technology, Yokohama, Japan.
Nucleosides & Nucleotides
|September 4, 1999
Abstract:
Triplex-stabilizing effect of a graft copolymer under physiologically relevant conditions has been evaluated and compared with other polyamines. Here we show that the graft copolymer significantly stabilizes triplex DNAs with amazingly higher efficacy than that of physiological concentrations of spermine and spermidine.