Thermodynamic studies on hairpin forming antisense-oligodeoxynucleotides directed against hepatitis C virus RNA

¹Institute of Organic Chemistry, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany.

Nucleosides & Nucleotides

|September 4, 1999

Abstract:

Phosphorothioate and benzyl-modified antisense-oligodeoxynucleotides directed against nucleotides 334-350 of the Hepatitis C Virus RNA form surprisingly stable hairpins. These data contribute to solve a structural detail information in search for a global secondary structure model of the Non Coding Region (NCR) of HCV.

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Abstract:

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