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Investigations into self-association of vancomycin covalent dimers using surface plasmon resonance technology
M Adamczyk1, J A Moore, S D Rege
1Department of Chemistry, Abbott Laboratories, Abbott Park, IL 60064-6016, USA.
Bioorganic & Medicinal Chemistry Letters
|September 7, 1999
Abstract:
Covalent dimers of vancomycin linked through the vancosamine sugar moieties of the glycopeptide antibiotic have been synthesized in one step in 67-69% yield. The propensity for self-association of these and related vancomycin covalent dimers is evaluated using surface plasmon resonance technology.