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Related Experiment Videos

The möbius sequence: a relook.

M T Miller1, K Strömland

  • 1Department of Ophthalmology, Eye and Ear Infirmary, University of Illinois at Chicago, 60612, USA. marimill@uic.edu

Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
|September 7, 1999
PubMed
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Mobius sequence, a developmental disorder, involves cranial nerve deficits and diverse malformations. Associated findings offer insights into the embryonic insult

Area of Science:

  • Neurology
  • Developmental Biology
  • Ophthalmology

Background:

  • Mobius syndrome is re-conceptualized as Mobius sequence, indicating secondary events post-embryonic insult.
  • Classic signs include cranial nerve VI and VII deficits, with limb, craniofacial, and other cranial nerve malformations.

Purpose of the Study:

  • To investigate the clinical spectrum and associated findings in patients with Mobius sequence.
  • To explore the developmental disturbances underlying Mobius sequence.

Main Methods:

  • A prospective study of 25 patients with characteristic Mobius sequence findings in Sweden.
  • Clinical assessment of ocular motility, facial nerve function, and associated systemic anomalies.

Main Results:

Related Experiment Videos

  • Ocular motility showed varied patterns, including limited abduction and horizontal gaze paresis; 10/25 had straight eyes.
  • Nineteen patients had diminished facial expression; associated anomalies included limb malformations (8), micrognathia (8), tongue malformations (17), and autism spectrum disorder (7).

Conclusions:

  • Associated findings in Mobius sequence provide clues to the timing and location of developmental disturbances.
  • The diverse ocular motility patterns challenge the notion of a lesion solely in the sixth nerve nucleus.