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Halisulfate 7, a new sesterterpene sulfate from a sponge, Coscinoderma sp
X Fu1, M L Ferreira, F J Schmitz
1Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, USA.
Journal of Natural Products
|September 10, 1999
Summary
Researchers discovered a new sesterterpene sulfate, named halisulfate 7, from a marine sponge. This compound was isolated from Coscinoderma sp. found in Micronesia.
Area of Science:
- Marine natural products chemistry
- Marine biology
- Organic chemistry
Background:
- Marine sponges are a rich source of structurally diverse secondary metabolites.
- Coscinoderma sp. sponges have yielded various bioactive compounds.
- Sesterterpenes are a class of terpenoids with 20 carbon atoms.
Purpose of the Study:
- To isolate and characterize new chemical entities from marine sponges.
- To investigate the chemical diversity of Coscinoderma sp.
Main Methods:
- Isolation of compounds using chromatographic techniques.
- Structure elucidation using spectroscopic methods (NMR, MS).
Main Results:
- A novel sesterterpene sulfate, designated halisulfate 7 (1), was isolated.
- The chemical structure of halisulfate 7 was determined through comprehensive spectroscopic analysis.
Conclusions:
- Halisulfate 7 represents a new addition to the known sesterterpene sulfates.
- The discovery highlights the potential of marine sponges as a source for novel chemical structures.