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Systemic reactions to allergy skin tests.

M A Valyasevi1, D E Maddox, J T Li

  • 1Allergy and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|September 10, 1999
PubMed
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Allergy skin tests are generally safe, with a very low rate of systemic reactions. When reactions occur, they are typically mild and resolve quickly, allowing patients to recover within an hour.

Area of Science:

  • Allergy diagnostics
  • Immunology
  • Clinical safety

Background:

  • Skin testing is a standard diagnostic method for allergies.
  • While generally safe, systemic reactions to skin tests can occur.

Purpose of the Study:

  • To determine the incidence of systemic reactions during allergy skin testing.
  • To evaluate the clinical outcomes of these systemic reactions.

Main Methods:

  • Retrospective analysis of a computerized database from Mayo Clinic (January 1992 - June 1997).
  • Included 497,656 skin tests across 18,311 patients.
  • Identified and evaluated systemic reactions managed by physicians.

Main Results:

  • Overall systemic reaction rate was 33 per 100,000 tests.

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  • Specific rates varied by allergen type (e.g., latex, penicillin, aeroallergens).
  • All six patients experiencing reactions had asthma and recovered within one hour.

    • Conclusions:

    • Systemic reactions to allergy skin tests are rare.
    • Reactions observed were mild and led to full recovery within an hour.