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[Pleiotropic effects of garlic].

G Siegel1, A Walter, S Engel

  • 1Institut für Physiologie, Universitätsklinikums Benjamin Franklin, Freien Universität Berlin, Deutschland. siegel@mail.grumed.fu-berlin.de

Wiener Medizinische Wochenschrift (1946)
|September 14, 1999
PubMed
Summary

Garlic supplements significantly reduce arteriosclerosis plaque volume by up to 18% and lower cardiovascular risk. This herbal remedy improves cholesterol levels, blood pressure, and blood flow, offering substantial heart health benefits.

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Area of Science:

  • Cardiovascular Medicine
  • Pharmacology
  • Herbal Medicine

Context:

  • Arteriosclerosis poses a significant health risk, driven by factors like high cholesterol, blood pressure, and blood viscosity.
  • Garlic is a widely used herbal remedy with a long history of medicinal applications.

Purpose:

  • To evaluate the efficacy of standardized garlic powder in reducing arteriosclerotic plaque volume and mitigating cardiovascular risk factors.
  • To investigate the pleiotropic effects of garlic on lipid profiles, blood pressure, and vascular function.

Summary:

  • A 4-year clinical trial demonstrated that daily intake of standardized garlic powder (900 mg) reduced arteriosclerotic plaque volume by 9-18% and achieved 3% regression.
  • Garlic supplementation led to significant improvements: a 4% decrease in LDL cholesterol, an 8% increase in HDL cholesterol, and a 7% reduction in blood pressure.

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  • The blood pressure reduction is attributed to garlic's action on K(Ca) ion channels, causing hyperpolarization, vasodilatation, and improved coronary perfusion by 18%.

    • Impact:

    • Garlic's pleiotropic effects result in a greater than 50% reduction in relative cardiovascular risk for myocardial infarction and stroke.
    • This study validates garlic's role as a potent natural intervention for managing arteriosclerosis and preventing major cardiovascular events.
    • The findings support the integration of garlic-based therapies into cardiovascular disease prevention strategies.