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Soluble CD23 in allergic diseases.

B Rogala1, B Rymarczyk

  • 1Department and Clinic of Allergic and Internal Diseases, Silesian School of Medicine, Zabrze, Poland.

Archivum Immunologiae Et Therapiae Experimentalis
|September 14, 1999
PubMed
Summary

Soluble CD23 (sCD23) serum levels are elevated in patients with allergic diseases, including pollinosis and insect venom allergies. However, sCD23 levels showed no correlation with immunoglobulin E (IgE) levels in these patients.

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Area of Science:

  • Immunology
  • Allergy Research
  • Biochemistry

Background:

  • CD23, the low-affinity receptor for IgE (FcepsilonRII), is a B cell marker.
  • Autoproteolysis cleaves CD23 into soluble fragments (sCD23), acting as a multifunctional cytokine.
  • sCD23 is implicated in immunoglobulin E (IgE) synthesis, a key factor in allergic diseases.

Purpose of the Study:

  • To investigate serum levels of soluble CD23 (sCD23) in patients with inhalant allergies and hymenoptera venom allergies.
  • To assess the relationship between sCD23 levels and the immunoglobulin E (IgE) system in allergic individuals.

Main Methods:

  • Serum samples were collected from patients with pollinosis (n=18), house dust mite allergy (n=25), hymenoptera venom allergy (n=12), and healthy controls (n=18).
  • Serum levels of sCD23 (25 kDa), total IgE, and allergen-specific IgE were quantified.
  • Statistical analysis included nonparametric tests (Mann-Whitney U, Kruskal-Wallis, Spearman correlation).

Main Results:

  • Patients with allergic disorders exhibited significantly higher serum sCD23 levels compared to the control group (p<0.05).
  • No significant correlation was found between sCD23 levels and total or specific IgE levels across all investigated groups.
  • Elevated sCD23 levels were observed irrespective of the type of allergic disease.

Conclusions:

  • Serum sCD23 levels are significantly elevated in patients with allergic disorders.
  • sCD23 does not appear to be a direct hallmark or correlate of IgE levels in allergic diseases.
  • The study suggests sCD23 elevation is a general finding in allergic conditions, independent of IgE levels or disease type.

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