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First-pass renal perfusion imaging using MS-325, an albumin-targeted MRI contrast agent
P V Prasad1, J Cannillo, D R Chavez
1Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.
Rationale And Objectives:
MR angiography is proving to be a useful clinical study for the diagnosis of vascular disorders of renal arteries. However, its utility in terms of stenosis characterization is still limited. Renal perfusion could provide supplemental information that could allow for a comprehensive evaluation of renal artery stenosis by MR imaging.
Methods:
MS-325 is a small-molecule blood pool agent that reversibly binds with serum albumin and hence leads to higher relaxivity and longer residence times in the blood. In this study, the authors evaluated the use of MS-325 to perform first-pass perfusion imaging and contrast-enhanced MR angiography in the characterization of renal artery stenosis in an animal model.
Results:
Quantitative perfusion estimates were obtained in the renal cortex (258 +/- 19.8 mL/min/100 g) and are comparable to microsphere measurements (198 +/- 12.2 mL/min/100 g), given the practical constraints. Based on these measurements, perfusion showed minimal changes even when the diameter reductions reached 75%.
Conclusions:
MS-325 could provide quantitative perfusion estimates that when combined with MR angiography may lead to comprehensive evaluation of renal artery stenosis.
Insights
New MR imaging techniques using MS-325 show promise for evaluating renal artery stenosis. This method provides quantitative perfusion estimates, improving the comprehensive assessment of kidney artery conditions.
Area of Science:
- Radiology
- Medical Imaging
- Vascular Imaging
Background:
- Magnetic resonance (MR) angiography is valuable for diagnosing renal artery disorders.
- Current MR angiography has limitations in characterizing renal artery stenosis.
- Renal perfusion imaging may offer supplemental data for comprehensive evaluation.
Purpose of the Study:
- To evaluate MS-325 for first-pass perfusion imaging and contrast-enhanced MR angiography.
- To assess the characterization of renal artery stenosis in an animal model using MS-325.
Main Methods:
- MS-325, a blood pool agent with enhanced relaxivity and blood residence time, was administered.
- First-pass perfusion imaging and contrast-enhanced MR angiography were performed.
- Quantitative perfusion estimates were obtained in the renal cortex.
Main Results:
- Renal cortical perfusion estimates (258 +/- 19.8 mL/min/100 g) were comparable to microsphere measurements (198 +/- 12.2 mL/min/100 g).
- Perfusion demonstrated minimal changes despite up to 75% diameter reduction in renal arteries.
- MS-325 facilitated both perfusion imaging and MR angiography.
Conclusions:
- MS-325 enables quantitative perfusion estimation in the kidneys.
- Combining MS-325-based perfusion imaging with MR angiography offers a comprehensive approach to evaluating renal artery stenosis.
- This integrated MR imaging technique enhances the diagnostic utility for renal vascular disorders.