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Related Experiment Video

Updated: Jul 17, 2026

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
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An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells

Published on: July 15, 2015

Ultra-High-Resolution Dual-Source Photon-Counting CT for Expanded Characterization of Pathophysiological Imaging

Anke Heidemeier1, Henner Huflage, Leo Rasche

  • 1Departments of Diagnostic and Interventional Radiology (A.H., H.H., T.A.B., J.-P.G.); Internal Medicine 2, University Hospital Würzburg, Würzburg, Germany (L.R., K.M.K., J.M.W., H.E.).

Investigative Radiology
|July 16, 2026
PubMed
Summary

Dual-source photon-counting CT (DS-PCCT) reveals a new fat-attenuation imaging phenotype in multiple myeloma (MM). This spectral-morphologic analysis aids in differentiating MM from precursor conditions.

Keywords:
bone marrow assessmentlow-keV imagingmultiple myelomaphoton-counting CTvirtual monoenergetic imagingwhole-body CT

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Monitoring Tumor Metastases and Osteolytic Lesions with Bioluminescence and Micro CT Imaging
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Monitoring Tumor Metastases and Osteolytic Lesions with Bioluminescence and Micro CT Imaging

Published on: April 14, 2011

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Last Updated: Jul 17, 2026

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09:41

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Published on: July 15, 2015

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice
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Monitoring Tumor Metastases and Osteolytic Lesions with Bioluminescence and Micro CT Imaging
08:04

Monitoring Tumor Metastases and Osteolytic Lesions with Bioluminescence and Micro CT Imaging

Published on: April 14, 2011

Area of Science:

  • Radiology
  • Oncology
  • Medical Imaging

Background:

  • Multiple myeloma (MM) skeletal assessment relies on imaging, but current methods may miss certain lesion types.
  • Dual-source photon-counting CT (DS-PCCT) offers high spatial resolution and spectral data for enhanced tissue characterization.

Purpose of the Study:

  • To assess axial and appendicular skeletal manifestations in multiple myeloma (MM) at initial diagnosis using DS-PCCT.
  • To exploit attenuation characteristics in low-keV virtual monoenergetic images (VMI) for spectral-morphologic analysis.

Main Methods:

  • Retrospective analysis of whole-body DS-PCCT data from 84 patients (53 MM, 31 precursor conditions).
  • Radiologists measured CT attenuation of osteolytic lesions and femoral bone marrow at 40 and 70 keV.
  • Evaluated long bones for specific marrow patterns and endosteal scalloping.

Main Results:

  • DS-PCCT identified three imaging phenotypes in MM patients: soft-tissue-attenuation (47.2%), fat-attenuation (18.9%), and mixed (9.4%).
  • A fat-attenuation phenotype was observed in MM, distinct from precursor conditions.
  • Low-keV VMI showed energy-dependent attenuation, aiding pattern differentiation; inter-reader agreement was good to excellent.

Conclusions:

  • DS-PCCT identified a novel fat-attenuation phenotype in MM, potentially representing symptomatic bone disease not meeting current criteria.
  • Spectral-morphologic characterization complements existing imaging, aiding differentiation between overt MM and nonspecific marrow abnormalities.