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Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Updated: May 9, 2026

In vivo 19F MRI for Cell Tracking
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In vivo 19F MRI for Cell Tracking

Published on: November 25, 2013

First In-vivo Human Magnetic Particle Imaging.

Patrick Vogel1,2, Thomas Kampf1,3, Martin Andreas Rückert1

  • 1Julius-Maximilians University, Department of Experimental Physics 5 (Biophysics), Germany, Würzburg.

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|May 7, 2026
PubMed
Summary
This summary is machine-generated.

First-in-human magnetic particle imaging (MPI) angiography successfully visualized veins in real-time without radiation. This radiation-free imaging modality showed comparable results to conventional angiography, paving the way for clinical applications.

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Last Updated: May 9, 2026

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Area of Science:

  • Medical Imaging
  • Biomedical Engineering
  • Radiology

Background:

  • Magnetic Particle Imaging (MPI) is an emerging tracer-based imaging technique.
  • MPI offers radiation-free visualization with high temporal resolution.
  • Previous in-vivo human applications of MPI have not been reported.

Purpose of the Study:

  • To demonstrate the feasibility of the first in-human MPI angiography.
  • To compare MPI angiography with conventional X-ray digital subtraction angiography (DSA).

Main Methods:

  • A first-in-human MPI angiography was performed on a healthy volunteer.
  • A human-scale interventional MPI scanner and ferucarbotran tracer were used.
  • Imaging was conducted under clinical conditions, with DSA performed for comparison.

Main Results:

  • MPI successfully visualized major superficial and deep veins, including inflow, branching, valves, and collateral pathways.
  • The spatial and temporal resolution of MPI was comparable to DSA.
  • No adverse events were reported during the procedure.

Conclusions:

  • First in-vivo human MPI angiography is feasible.
  • MPI provides real-time, radiation-free angiographic visualization.
  • MPI shows potential for selected vascular and interventional clinical applications.