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Ocular physiology and artificial tears
A López-Alemany1, R Montés-Micó, M García-Valldecabres
1Departament d'Optica, Facultat de Física, Universitat de València, Spain.
Journal of the American Optometric Association
|September 15, 1999
Summary
Artificial tears solutions generally maintain a stable pH within the ocular comfort range, showing no significant changes over 60 days. This stability ensures they are safe for ocular physiology and contact lens wear.
Area of Science:
- Ophthalmology
- Optometry
- Biomedical Engineering
Background:
- Artificial tears are formulated to match the ocular comfort range and physiological tear pH.
- Evaluating the pH stability of artificial tears is crucial for ocular health.
Purpose of the Study:
- To assess the pH stability of nine artificial tears solutions over a 60-day period.
- To determine if artificial tears' pH remains within the ocular comfort range over time.
Main Methods:
- Randomly selected 15 bottles from different production lots for each of the nine artificial tears solutions.
- Measured pH daily using a micropH 2002 Crison pH-meter over 60 days, with daily 0.05 ml increments.
Main Results:
- All tested artificial tears solutions maintained pH values within the ocular comfort range.
- No statistically significant pH variations were observed over the 60-day study period (p > 0.01).
- Significant differences in pH were noted between various artificial tears solutions, with some closer to physiological tear pH than others.
Conclusions:
- The evaluated artificial tears solutions are unlikely to negatively impact ocular physiology or contact lens wear.
- Healthcare practitioners should be aware of individual artificial tears solution properties to select appropriate options for patients.