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Plasma choline concentrations in children requiring long-term home parenteral nutrition: a case control study
1Division of Pediatric Gastroenterology and Nutrition, UCLA School of Medicine, California, USA.
Insights
Children needing long-term home parenteral nutrition (HPN) show significantly lower plasma free choline levels. This deficiency is linked to increased liver enzymes, indicating a risk for hepatic dysfunction in these patients.
Area of Science:
- Biochemistry
- Pediatric Nutrition
- Hepatology
Background:
- Low plasma free choline is linked to liver issues in adults on home parenteral nutrition (HPN).
- The status of plasma free choline in children requiring home total parenteral nutrition (TPN) is not well-established.
Purpose of the Study:
- To investigate plasma free choline concentrations in children requiring long-term HPN.
- To compare choline levels in HPN-dependent children with healthy controls.
Main Methods:
- Plasma free choline was measured in 21 children on long-term HPN and 31 healthy controls.
- Statistical analyses, including multiple linear regression, were used to assess correlations with age and liver enzymes.
Main Results:
- Children on HPN had significantly lower plasma free choline than controls (6.6 vs 8.0 nmol/mL).
- Plasma free choline declined with age in HPN children and correlated negatively with AST and ALT levels.
- No association was found between choline levels and daily IV lipid infusion amounts.
Conclusions:
- Children requiring long-term HPN without enteral feeding are at risk of choline deficiency.
- Choline deficiency in these pediatric patients may contribute to hepatic dysfunction.
Background:
Low plasma free choline concentration has been associated with elevated serum hepatic aminotransferase concentrations and hepatic steatosis in adults who need home parenteral nutrition (HPN). We sought to determine if plasma free choline is similarly reduced in children who need home total parenteral nutrition (TPN).
Methods:
We compared the plasma free choline concentration in 21 children who required long-term HPN with 31 normal controls. Patients had received HPN for 75 +/- 13 (SD) months (range 3-206 months). All control children ingested a normal, mixed, nonvegetarian diet.
Results:
The mean plasma free choline concentration in the children receiving HPN was significantly lower than normal children (6.6 +/- 4.3 vs 8.0 +/- 2.3 nmol/mL, p = .002). Plasma free choline concentration was correlated with age (r = -0.43, p = .049). Using multiple linear regression analysis for age, sex, and squared age (considered in order to account for possible nonlinearity between choline and age), HPN children showed a steady and significant decline in plasma free choline concentration with increased age at the rate of 0.03 nmol/mL per month. Plasma lipid bound choline concentration did not vary with age. No relationship was seen between either plasma free and lipid bound choline concentration and amount of daily IV lipid infusion. A significant negative correlation was observed between plasma free choline concentration and aspartate aminotransferase (AST) and alanine aminostransferase (ALT) (r = -0.72, p = .04 and r = -0.80, p = .02, respectively).
Conclusion:
Our data support the notion that patients who need long-term HPN without significant enteral feeding have a significant risk for the development of choline deficiency with its associated hepatic dysfunction.
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