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Development of the receptor database (RDB): application to the endocrine disruptor problem
K Nakata1, T Takai, T Kaminuma
1Division of Chem-Bio Informatics, National Institute of Health Sciences, 1-18-1, Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan. nakata@nihs.go.jp
Bioinformatics (Oxford, England)
|September 17, 1999
Summary
The Receptor Database (RDB) integrates protein data from the internet using ACEDB and WWW technology. This system offers effective data viewing tools for receptor research, including applications for endocrine disruptors.
Area of Science:
- Bioinformatics
- Molecular Biology
- Database Management
Background:
- Developing effective representations for diverse receptor aspects is crucial.
- Existing biological databases are distributed and require integration.
- Object-oriented database management systems and internet technologies offer solutions.
Purpose of the Study:
- To develop a comprehensive Receptor Database (RDB).
- To integrate data from distributed biological sources.
- To provide effective data visualization tools for receptor research.
Main Methods:
- Utilized the ACEDB object-oriented database management system.
- Leveraged Internet/WWW technologies for data collection and access.
- Integrated data from international biological databases (PIR, Swiss Prot, PDB, GenBank, GDB).
Main Results:
- The RDB system successfully collects protein attributes from distributed sources.
- Provided diverse viewing tools tailored to different receptor data types.
- Demonstrated application in studying endocrine disruptors.
Conclusions:
- The Receptor Database (RDB) provides a unified platform for receptor data.
- Effective integration and visualization of biological data are achievable.
- RDB can support research on complex biological problems like endocrine disruption.