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Related Experiment Videos

Cyclic vomiting syndrome: features to be explained by a pathophysiologic model.

B U Li1, D R Fleisher

  • 1Department of Pediatrics, The Ohio State University, Columbus, USA.

Digestive Diseases and Sciences
|September 18, 1999
PubMed
Summary
This summary is machine-generated.

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Cyclic vomiting syndrome (CVS) is a disorder causing episodic vomiting, often starting in childhood. Current research explores potential triggers and underlying mechanisms, with promising treatments emerging.

Area of Science:

  • Gastroenterology
  • Pediatrics
  • Neurology

Background:

  • Cyclic vomiting syndrome (CVS) is characterized by stereotypic episodes of intense nausea and vomiting with periods of wellness in between.
  • The exact cause of CVS is unknown, but it often affects children and resolves by adolescence.
  • Vomiting episodes can be triggered by physical or psychological stress.

Purpose of the Study:

  • To review the clinical presentation, potential triggers, and current understanding of the pathogenesis of cyclic vomiting syndrome.
  • To discuss the diagnostic challenges and emerging treatment options for CVS.

Main Methods:

  • Literature review of studies on cyclic vomiting syndrome.
  • Analysis of clinical patterns, triggers, and proposed mechanisms.

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  • Evaluation of current and future therapeutic strategies.

    • Main Results:

    • CVS presents with rapid-onset, stereotypic vomiting episodes, often accompanied by pallor, lethargy, and abdominal pain.
    • Differential diagnosis is crucial as CVS can mimic various medical conditions.
    • Serotonergic agents show promise in treatment, and potential mechanisms include migraine, metabolic, neuroendocrine, and gastrointestinal factors.

    Conclusions:

    • Cyclic vomiting syndrome is a distinct disorder requiring careful diagnosis by exclusion.
    • Understanding the underlying mechanisms, such as migraine or metabolic dysfunction, is key to developing effective treatments.
    • CVS serves as a valuable model for studying the complex process of emesis.