The influence of mRNA stability on glucose transporter (GLUT1) gene expression
1School of Medicine, East Carolina University, Greenville, North Carolina, 27858-4354, USA.
Abstract:
One mechanism for modification of glucose transport activity occurs through regulation of the cellular content of transporter protein by alteration of transcript stability. Regulated mRNA decay has been shown to play an important role in control of posttranscriptional gene expression. Implicated, as a pivotal element in this regulation is the 3'-untranslated region (UTR) of the message. Recent work from several labs has focused on sequence motifs within the 3'-UTR of glucose transporter (GLUT1) mRNA that serve as destabilizing or stabilizing elements and recognition of these elements by specific proteins. In this review, we address several critical studies each of which has identified elements in the GLUT1 3'-UTR that are involved in the control of transcript stability and demonstrated that these sequence motifs are recognized by specific binding proteins.
More Related Videos
Related Concept Videos
RNA Stability
mRNA Stability and Gene Expression
Cis-acting Elements involved in mRNA stability
Glucose Transporters
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Regulated mRNA Transport
mRNA Stability and Gene Expression
Cis-acting Elements involved in mRNA stability
Regulation of Expression at Multiple Steps


