Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Selective gene expression increases behavioral sensitivity to cocaine.

S E Hyman1

  • 1National Institute of Mental Health, National Institutes of Health, 6001 Executive Boulevard, Room 8235, MSC 9669, Bethesda, Maryland 20892-9669, USA. shyman@nih. gov.

Nature Neuroscience
|September 24, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An integrated preclerkship curriculum in neuroscience, psychiatry, and neurology.

Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry·2014
Same author

Neurologic education for the future: a decade of curricular reform at Harvard Medical School.

European journal of neurology·2013
Same author

Exploring the feasibility of a meta-structure for DSM-V and ICD-11: could it improve utility and validity?

Psychological medicine·2009
Same author

Inhibiting activator protein-1 activity alters cocaine-induced gene expression and potentiates sensitization.

Neuroscience·2008
Same author

Mental health in an aging population: the NIMH perspective.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry·2001
Same author

A 28-year-old man addicted to cocaine.

JAMA·2001
Same journal

Neural timescales from a computational perspective.

Nature neuroscience·2026
Same journal

Author Correction: Spinal cord Tau pathology induces tactile deficits and cognitive impairment in Alzheimer's disease via dysregulation of CCK neurons.

Nature neuroscience·2026
Same journal

Hippocampal theta sweeps indicate goal direction during navigation.

Nature neuroscience·2026
Same journal

Just how goal-directed are hippocampal theta sweeps, anyway?

Nature neuroscience·2026
Same journal

Goal-directed hippocampal theta sweeps during memory-guided navigation.

Nature neuroscience·2026
Same journal

Connectomic evidence that ordered activity drives neuromuscular network formation.

Nature neuroscience·2026
See all related articles

Addictive drugs alter fosB protein in the brain. Mice with this altered fosB expression show increased sensitivity to cocaine, suggesting a role in addiction.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Addiction Research

Background:

  • Addictive drugs are known to alter gene expression in the brain's reward pathways.
  • The FosB protein, specifically a truncated form, has been implicated in the long-term effects of chronic drug exposure.
  • The striatum is a key brain region involved in reward processing and motor control, heavily affected by addictive substances.

Purpose of the Study:

  • To investigate the functional role of the truncated fosB protein in the striatum.
  • To determine if mimicking the truncated fosB expression pattern in mice affects their response to addictive drugs.
  • To explore the potential link between fosB modifications and heightened sensitivity to cocaine.

Main Methods:

  • Utilizing genetic engineering to create mouse models with a specific truncated fosB expression pattern in the striatum.

Related Experiment Videos

  • Administering cocaine to engineered mice and control groups.
  • Behavioral analysis to assess the sensitivity and response to cocaine.

    • Main Results:

    • Mice engineered to express the truncated fosB form in the striatum exhibited significantly increased sensitivity to cocaine.
    • This heightened sensitivity suggests a direct role of the truncated fosB protein in mediating drug-induced behavioral changes.
    • The study provides a direct link between a specific molecular alteration (truncated fosB) and a behavioral phenotype (cocaine sensitivity).

    Conclusions:

    • The truncated form of fosB in the striatum plays a critical role in mediating behavioral responses to addictive drugs like cocaine.
    • Mimicking the expression pattern of truncated fosB is sufficient to induce abnormal sensitivity to cocaine.
    • These findings highlight truncated fosB as a potential molecular target for understanding and treating drug addiction.