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Dextromethorphan O-demethylation polymorphism in an African-American population
1Clinical Pharmacology Program, Department of Pharmacology, Meharry Medical College, Nashville, TN 37208, USA. henunn54@ccvax.mmc.edu
Objective:
One hundred eighty-one (97 F, 84 M) unrelated healthy African-American subjects (aged 18-41 years) were phenotyped based on their dextromethorphan (DMP) O-demethylation ability.
Methods:
Each subject was given 15 mg DMP orally and collected 8-h urine. The concentrations of DMP and its metabolite dextrophan (DOP) were determined by HPLC with ultraviolet detection. Metabolic ratio (MR) was expressed as the ratio of DMP to DOP molar amount in urine.
Results:
The frequency distribution histogram of the MR was bimodal, and probit analysis of this frequency gave an antimode value of 0.34. Seven subjects [3.9%, 95% confidence interval (CI) 1.1%-6.7%] were classified as poor metabolizers (PMs).
Conclusion:
This deficient frequency is in complete agreement with the reported ones in two smaller investigations in the African-American populations.