Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Factors predicting atracurium reversal time.

H Kirkegaard-Nielsen1, I K Severinsen, H S Pedersen

  • 1Department of Anaesthesia and Intensive Care, Odense University Hospital, Denmark.

Acta Anaesthesiologica Scandinavica
|September 24, 1999
PubMed
Summary

Predictors of reversal time from atracurium block vary by block depth. The first twitch (T1) is key in superficial blocks, while initial dose duration and pre-reversal time become important in deeper blocks.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Influence of Hyperoxic-Supplemented High-Intensity Interval Training on Hemotological and Muscle Mitochondrial Adaptations in Trained Cyclists.

Frontiers in physiology·2019
Same author

Craniomaxillofacial osteosarcoma - The role of surgical margins.

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery·2019
Same author

Effect of cumulus cells and sperm concentration on fertilization and development of pig oocytes.

Reproduction in domestic animals = Zuchthygiene·2018
Same author

Neurotransmitters behind pain relief with transcranial magnetic stimulation - positron emission tomography evidence for release of endogenous opioids.

European journal of pain (London, England)·2017
Same author

Role of two sequence motifs of mesencephalic astrocyte-derived neurotrophic factor in its survival-promoting activity.

Cell death & disease·2016
Same author

No association between body mass index and sperm DNA integrity.

Human reproduction (Oxford, England)·2015

Area of Science:

  • Anesthesiology
  • Pharmacology
  • Neuromuscular Blockade

Background:

  • Atracurium is a common neuromuscular blocking agent.
  • Reversal time from neuromuscular blockade is critical for patient safety.
  • Predicting reversal time aids in optimizing anesthetic management.

Purpose of the Study:

  • To identify factors predicting reversal time after atracurium-induced neuromuscular block.
  • To evaluate the influence of block depth on reversal time predictors.

Main Methods:

  • 83 female patients (ASA I-II) received atracurium.
  • Neuromuscular block was monitored using mechanomyography (train-of-four or double-burst stimulation).
  • Reversal time was measured from neostigmine administration to a train-of-four ratio of 0.70.

Related Experiment Videos

Main Results:

  • With superficial block (T1 >15%), T1 was the sole significant predictor of reversal time.
  • In moderate block (0< T1 ≤15%), both T1 and the duration of the initial atracurium dose predicted reversal time.
  • For profound block (T1=0), the initial dose duration and pre-reversal time were significant predictors.

Conclusions:

  • The first twitch (T1) is a more reliable predictor than D1 for reversal time.
  • Predictors of atracurium reversal time are dependent on the degree of neuromuscular block.
  • Clinical assessment of block depth is crucial for anticipating reversal time.