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Stability of cefepime in peritoneal dialysis solution
J C Williamson1, D F Volles, P L Lynch
1Department of Pharmacy, University of Virginia Health System, Charlottesville, USA. jcwunc@belsouth.net
The Annals of Pharmacotherapy
|September 24, 1999
Summary
Cefepime is stable in peritoneal dialysis solution for extended periods. It remains effective for 14 days when refrigerated, 7 days at room temperature, and 48 hours at body temperature.
Area of Science:
- Pharmaceutical Sciences
- Nephrology
- Infectious Diseases
Background:
- Peritoneal dialysis (PD) is a crucial treatment for kidney failure.
- The stability of antibiotics in PD solutions is vital for effective infection management during treatment.
Purpose of the Study:
- To assess the stability of cefepime, a broad-spectrum antibiotic, when mixed with a standard peritoneal dialysis solution.
- To provide data supporting the safe co-administration of cefepime with PD fluids.
Main Methods:
- Cefepime hydrochloride was added to Delflex PD solution with 1.5% dextrose.
- Solutions were stored at 4°C, 25°C, and 37°C.
- Cefepime concentrations were quantified using High-Performance Liquid Chromatography (HPLC) over various time points.
Main Results:
- Cefepime concentrations consistently remained above 90% of the initial concentration under all tested conditions.
- The drug demonstrated significant stability across refrigeration, room temperature, and body temperature simulations.
Conclusions:
- Cefepime is chemically stable in 1.5% dextrose PD solution.
- The recommended storage durations are 14 days (refrigerated), 7 days (room temperature), and 48 hours (37°C).