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Related Experiment Videos

Fatal fulminant hepatitis associated with bromfenac use.

J M Rabkin1, M J Smith, S L Orloff

  • 1Department of Surgery, Oregon Health Sciences University, and Portland Veterans Affairs Medical Center, 97201, USA. rabkinj@ohsu.edu

The Annals of Pharmacotherapy
|September 24, 1999
PubMed
Summary

Fulminant hepatic failure, a severe liver condition, was linked to bromfenac, a nonsteroidal anti-inflammatory drug. This adverse event highlights potential risks associated with phenyl acetate analogs.

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Area of Science:

  • Hepatology
  • Pharmacology
  • Toxicology

Background:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used for pain management.
  • Bromfenac, a phenyl acetate derivative NSAID, was prescribed for arthritic pain.
  • Patient had no prior history of chronic liver disease.

Observation:

  • A 60-year-old woman developed fulminant hepatic failure after three months of bromfenac use.
  • Her liver function tests were normal before initiating bromfenac.
  • Deterioration included hepatic encephalopathy and worsening liver function despite medical care.

Findings:

  • The case suggests an idiosyncratic hepatotoxic reaction to bromfenac.
  • Prolonged use of bromfenac was associated with severe liver injury.

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  • The patient experienced progressive hepatic and renal dysfunction.

    • Implications:

    • This case contributed to understanding the hepatotoxicity of phenyl acetate NSAIDs.
    • Serious adverse events associated with bromfenac led to its market withdrawal.
    • Highlights the importance of monitoring liver function during NSAID therapy.