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Calcinosis cutis associated with systemic blastomycosis in three dogs
K Gortel1, B C McKiernan, J K Johnson
1Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana 61802, USA.
Journal of the American Animal Hospital Association
|September 24, 1999
Summary
Systemic blastomycosis treatment in dogs using amphotericin B led to calcinosis cutis in three cases. This skin condition resolved with minimal intervention, suggesting a manageable side effect of antifungal therapy.
Area of Science:
- Veterinary Medicine
- Mycology
- Dermatology
Background:
- Systemic blastomycosis is a fungal infection requiring aggressive treatment.
- Amphotericin B and its lipid complex are common antifungal agents used in veterinary medicine.
Observation:
- Three dogs receiving amphotericin B for blastomycosis developed calcinosis cutis.
- The skin calcification appeared 2-6 weeks after starting treatment.
- Serum calcium and phosphorus levels were largely normal during treatment and diagnosis.
Findings:
- Calcinosis cutis was observed in dogs treated for systemic blastomycosis.
- The condition was not linked to blastomycosis skin lesions.
- Skin calcification resolved spontaneously or with palliative care in all affected dogs.
Implications:
- Calcinosis cutis is a potential, albeit rare, side effect of amphotericin B therapy in dogs.
- Monitoring for skin changes during antifungal treatment is advisable.
- The condition appears to be self-limiting and manageable.