[Supportive therapy in patients with autologous hemopoietic stem cell transplantation]

Infectious complications remain one of the most serious diagnostic and therapeutic problems in modern hematology and are the major cause of morbidity and mortality following stem cell transplantation. Myeloablative therapy supported by haemopoietic stem cell transplantation remains standard policy in the treatment of certain haematological malignancies and solid tumors. Proper preventive strategies for patients in deep immunosuppression including prompt diagnosis and treatment of infections correlate with favourable prognosis and survival. Prophylaxis and therapy of bacterial, fungal and viral infections in neutropenic patients following myeloablative chemotherapy have been submitted in this article. Our guidelines are based on European Group for Bone and Marrow Transplantation recommendations and some European transplantological centres protocols. These standards were adapted to Polish conditions and now are used at Bone Marrow Transplantation Ward at Haematology Department at the Jagiellonian University.