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Updated: Jan 8, 2026

Workflow and Tools for Crystallographic Fragment Screening at the Helmholtz-Zentrum Berlin

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Published on: March 3, 2021

Optimizing coded-apertures for depth-resolved diffraction.

D Gürsoy¹, D Sheyfer¹, M Wojcik¹

¹Advanced Photon Source, Argonne National Laboratory, 9700 S Cass Ave., Lemont, Illinois 60439, USA.

The Review of Scientific Instruments

|December 15, 2025

Summary

This summary is machine-generated.

Coded apertures enable depth-resolved imaging in microscale diffraction experiments. This study optimizes their design and acquisition for accurate 3D structural characterization, even with noise.

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Area of Science:

Materials Science
Crystallography
Imaging Techniques

Background:

Coded apertures, originating from X-ray astronomy, are increasingly used for depth-resolved imaging.
Synchrotron-based diffraction experiments benefit from advanced imaging methods for structural analysis.

Purpose of the Study:

To evaluate coded apertures for microscale diffraction imaging.
To determine how design and acquisition parameters affect depth-dependent signal reconstruction.
To provide a framework for implementing coded apertures in diffraction geometries.

Main Methods:

Systematic simulations to analyze the impact of bit size, aperture thickness, scan length, and pattern characteristics.
Development of metrics to quantify reconstruction accuracy and success.
Experimental validation using a synchrotron-based micro-diffraction setup.

Main Results:

Simulation results guided the optimization of coded aperture parameters.
Moderate scan lengths and mask aspect ratios proved effective for signal recovery.
Robust signal recovery was achieved even under noisy experimental conditions.

Conclusions:

Coded apertures offer a scalable, sample-motion-free approach for 3D structural characterization.
The study provides a practical framework for applying coded apertures in microscale diffraction.
Findings are particularly relevant for emerging synchrotron facilities and advanced materials analysis.