Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Vasoactive transmitters in the coronary circulation].

O Saetrum Opgaard1, L Edvinsson

  • 1Department of Pharmacology, College of Medicine, University of California, Irvine 92697-4625, USA.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|September 24, 1999
PubMed
Summary

Vasoactive substances from nerves, endothelial cells, and hormones regulate coronary blood flow. These substances influence coronary vessel tone, impacting blood flow regulation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Origin and Co-localization of nitric oxide synthase, CGRP, PACAP, and VIP in the cerebral circulation of the rat.

Microscopy research and technique·2001
Same author

Pathophysiology of primary headaches.

Current pain and headache reports·2001
Same author

4991W93 inhibits release of calcitonin gene-related peptide in the cat but only at doses with 5HT(1B/1D) receptor agonist activity?

Neuropharmacology·2001
Same author

Characterisation of the effects of a non-peptide CGRP receptor antagonist in SK-N-MC cells and isolated human cerebral arteries.

European journal of pharmacology·2001
Same author

Characterization of CGRP(1) receptors in the guinea pig basilar artery.

European journal of pharmacology·2001
Same author

A pathophysiological view of primary headaches.

Functional neurology·2001

Area of Science:

  • Cardiovascular Physiology
  • Neuroendocrinology

Context:

  • Human coronary arteries and veins possess perivascular nerve fibers.
  • These nerves contain various neuropeptides, including Neuropeptide Y, vasoactive intestinal peptide, substance P, and calcitonin gene-related peptide.

Purpose:

  • To explore the role of diverse vasoactive substances in regulating coronary resistance and blood flow.
  • To identify the sources and types of vasoactive substances within the coronary vasculature.

Summary:

  • Perivascular nerve fibers, coronary endothelial cells, and humoral factors like gonadal hormones modulate coronary resistance.
  • Neuropeptides such as Neuropeptide Y, vasoactive intestinal peptide, substance P, and calcitonin gene-related peptide are localized in specific nerve subpopulations.
  • Endothelial cells synthesize nitric oxide and endothelin, contributing to vascular tone regulation.

Related Experiment Videos

Impact:

  • Understanding these regulatory mechanisms is crucial for comprehending coronary blood flow dynamics.
  • Identifies key molecular players involved in maintaining vascular tone and blood flow in the heart.