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Related Experiment Videos

Persistent Sydenham's chorea.

F Cardoso1, A P Vargas, L D Oliveira

  • 1Movement Disorders Clinic, Department of Neurology, The Federal University of Minas Gerais, Belo Horizonte, Brazil.

Movement Disorders : Official Journal of the Movement Disorder Society
|September 24, 1999
PubMed
Summary
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Sydenham's chorea (SC) persists in half of patients. Female gender and carditis may indicate longer SC duration, suggesting potential risk factors for prolonged symptoms in rheumatic fever patients.

Area of Science:

  • Neurology
  • Rheumatology
  • Pediatrics

Background:

  • Sydenham's chorea (SC), a neurological manifestation of rheumatic fever (RF), typically resolves spontaneously.
  • However, a subset of patients experience persistent SC, necessitating further investigation into its duration and associated factors.

Purpose of the Study:

  • To determine the proportion of SC patients with symptom duration exceeding two years.
  • To identify clinical features that differentiate between short-term (Group 1) and long-term (Group 2) SC.

Main Methods:

  • Prospective study of 32 SC patients (July 1993-March 1998).
  • Data collected included gender, age at onset, presence of arthritis, carditis, family history of RF/SC, chorea distribution, and severity.
  • Patients were categorized into Group 1 (<2 years duration) and Group 2 (>2 years duration).

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Main Results:

  • Half of the patients (16/32) experienced SC lasting over two years (Group 2).
  • Group 2 showed a higher proportion of females (68.8% vs 50%) and carditis (50% vs 31.2%) compared to Group 1.
  • No statistically significant differences were found between groups for other clinical features, including arthritis, family history, or chorea severity.

Conclusions:

  • Sydenham's chorea persists in approximately 50% of affected individuals.
  • Female gender and the presence of carditis may be associated with a longer duration of SC, potentially indicating a more severe underlying disease process.