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Developmental expression of Mab21l2 during mouse embryogenesis.

R L Wong¹, K K Chan, K L Chow

¹Department of Biology, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong.

Mechanisms of Development

|September 24, 1999

Summary

The mab-21 gene is crucial for sensory organ development. A second mouse homolog, Mab21l2, shows broad expression, indicating diverse roles in vertebrate embryonic development.

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Area of Science:

Developmental Biology
Genetics
Molecular Biology

Background:

The mab-21 gene is essential for establishing sensory organ identity in *Caenorhabditis elegans*.
Mammalian homologs of mab-21 have been identified, with transcripts primarily found in the eye and cerebellum.

Purpose of the Study:

To investigate the expression profile of a second murine *mab-21* homolog, designated *Mab21l2*.
To understand the potential developmental functions of *Mab21l2* in vertebrates.

Main Methods:

Whole mount in situ hybridization was performed on mouse embryos from embryonic day 8.5 to day 15.
Expression patterns of *Mab21l2* were analyzed and compared to *Mab21l1*.

Main Results:

*Mab21l2* expression patterns partially overlapped with those of *Mab21l1*.

Related Experiment Videos

Strong *Mab21l2* expression was observed in the mid- and hindbrain, otic vesicle, optic vesicle, maxillary and mandibular processes, paraxial mesoderm, dorsal midline, limb bud, and developing digits.

Conclusions:

*Mab21l2* exhibits a distinct and broader expression profile compared to *Mab21l1*.
The diverse expression suggests *Mab21l2* plays significant roles in various aspects of vertebrate embryonic development, beyond sensory organ formation.