Related Experiment Video
Updated: Aug 17, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
"p53: Twenty Years On" in Trieste, Italy, May 20-22, 1999
T K Maclachlan1, R D Meng, W S El-Deiry
1Laboratory of Molecular Oncology, Howard Hughes Medical Institute, Department of Medicine, Philadelphia, PA 19104, USA.
Abstract:
Study of the p53 tumor suppressor has blossomed into a field of its own. From analysis of its mutations in several different cancers to deciphering the function of the protein in human cells, publications describing research on p53 annually number in the thousands. In the interest of presenting the most up-to-date information on the progress of cancer research involving p53, the workshop "p53: Twenty Years On" was organized in Trieste, Italy over May 20-22, 1999. The meeting highlighted some of the most exciting basic and clinical scientific findings on p53 within the last year.
Related Concept Videos
Negative Regulator Molecules
Covalently Linked Protein Regulators
These groups modify specific amino acids in a protein.
DNA Damage can Stall the Cell Cycle
Abnormal Proliferation
Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
DNA Damage Can Stall the Cell Cycle

