Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The irritable larynx syndrome.

M Morrison1, L Rammage, A J Emami

  • 1Pacific Voice Clinic, University of British Columbia, Vancouver General Hospital, Canada.

Journal of Voice : Official Journal of the Voice Foundation
|September 25, 1999
PubMed
Summary

Hyperfunctional laryngeal symptoms like dysphonia and laryngospasm may stem from neural plasticity in the brainstem. Gastroesophageal reflux, psychological factors, and viral illness can trigger these changes, leading to irritable larynx syndrome.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluating Sulfurization as a Blue Carbon Sink in a Southern California Salt Marsh.

Limnology and oceanography·2025
Same author

The mental health impacts of human-ecosystem-animal relationships: A systematic scoping review of Eco-, Planetary, and One Health approaches.

One health (Amsterdam, Netherlands)·2023
Same author

Effect of food additives on key bacterial taxa and the mucosa-associated microbiota in Crohn's disease. The ENIGMA study.

Gut microbes·2023
Same author

Distinctive gut microbiomes of ankylosing spondylitis and inflammatory bowel disease patients suggest differing roles in pathogenesis and correlate with disease activity.

Arthritis research & therapy·2022
Same author

Cognitive Dysfunction: Feasibility of a Brief Intervention to Help Breast Cancer Survivors.

Clinical journal of oncology nursing·2021
Same author

Novel strain-level resolution of Crohn's disease mucosa-associated microbiota via an ex vivo combination of microbe culture and metagenomic sequencing.

The ISME journal·2021

Area of Science:

  • Neurology
  • Otolaryngology
  • Speech Pathology

Background:

  • Hyperfunctional laryngeal symptoms, including muscular tension dysphonia, episodic laryngospasm, globus, and chronic cough, are common.
  • Etiological factors are diverse, often including gastroesophageal reflux, psychological issues, and dystonia.

Purpose of the Study:

  • To propose a unifying hypothesis for hyperfunctional laryngeal symptoms.
  • To investigate the role of neural plasticity in the brainstem's laryngeal control networks.
  • To define criteria for Irritable Larynx Syndrome (ILS).

Main Methods:

  • Studied 39 patients diagnosed with Irritable Larynx Syndrome based on specific inclusion criteria.
  • Assessed etiological factors such as gastroesophageal reflux, psychological conditions, and history of viral illness.

Related Experiment Videos

  • Proposed a hypothesis involving neural plastic changes in brainstem laryngeal control networks.

    • Main Results:

    • Gastroesophageal reflux was implicated in over 90% of patients.
    • Psychological factors were identified in approximately one-third of patients.
    • One-third of patients linked symptom onset to a viral illness, suggesting potential central nervous system changes.

    Conclusions:

    • A unifying hypothesis suggests neural plastic changes in brainstem nuclei underlie hyperkinetic laryngeal dysfunction (Irritable Larynx Syndrome).
    • This hypothesis integrates various etiologies and provides a framework for therapy and research.
    • The findings support the concept of a "spasm-ready" state in laryngeal control neurons triggered by stimuli.