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Published on: August 26, 2019
Genetic control of cortical regionalization and connectivity
J L Rubenstein1, S Anderson, L Shi
1Center for Neurobiology and Psychiatry, Department of Psychiatry, University of California at San Francisco, 94143-0984, USA. jlrr@cgl.ucsf.edu
Cerebral Cortex (New York, N.Y. : 1991)
|September 25, 1999
Summary
Genetic mechanisms control neocortex regionalization. Specific gene expression patterns in neonatal mice reveal boundaries that define functional areas of the cerebral cortex, highlighting intrinsic control over development.
Area of Science:
- Neuroscience
- Developmental Biology
- Genetics
Background:
- Neocortical regionalization and connectivity are crucial for brain function.
- Accumulating evidence points to intrinsic mechanisms governing cortical regional specification and differentiation.
Purpose of the Study:
- To review the genetic control of neocortex regionalization and connectivity.
- To describe gene expression patterns that demarcate functional areas in the neonatal mouse cerebral cortex.
Main Methods:
- Review of existing literature on genetic control of neocortical development.
- Analysis of gene expression patterns in neonatal mouse brains.
Main Results:
- Identified several genes (Id-2, Tbr-1, cadherin-6, cadherin-8, neuropilin-2, Wnt-7b, Eph-A7, RZR-beta) with spatially restricted expression.
- Observed that these gene expression boundaries correlate with distinct functional areas of the neonatal mouse cerebral cortex.
Conclusions:
- Intrinsic genetic mechanisms play a central role in specifying and differentiating cortical regions.
- Specific gene expression patterns serve as molecular markers for functional areas within the developing neocortex.
