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Proteolytic cleavage of the repressor (BlaI) of beta-lactamase synthesis in Staphylococcus aureus
R A Lewis1, S P Curnock, K G Dyke
1Department of Biochemistry, University of Oxford, UK.
FEMS Microbiology Letters
|September 28, 1999
Abstract:
The proteolytic cleavage of BlaI was shown to correlate with beta-lactamase synthesis in Staphylococcus aureus. BlaI was found to be autoregulatory when expressed from the blaZ promoter. Insertion of a 10-bp linker into the SnaBI site of blaRI resulted in constitutive synthesis of beta-lactamase.