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Rational, high quality laboratory monitoring before, during, and after infusion of prothrombin complex concentrates

W M Halbmayer1

  • 1Institut für Laboratoriumsmedizin, Zentrallaboratorium mit Thromboseambulanz am Krankenhaus der Stadt Wien-Lainz, Vienna, Austria. ham@lab.khl.magwien.gv.at

Thrombosis Research
|September 28, 1999
PubMed

Prothrombin complex concentrates (PCCs) have been used for over thirty years to treat or prevent bleeding due to hemophilia B, vitamin K deficiency, warfarin overdose, liver disease, or deficiency of one of the prothrombin complex factors. This article tries to answer the questions of which profile of laboratory assays is required for the establishment of the diagnosis; what are indications of replacement therapy with PCCs; how to monitor the therapeutic effect; and how to monitor a possible prethrombotic state after PCC infusion. After proposing basic, standard, and optimal profiles of hemostaseological assays, the basic principal characteristics of a quality management satisfying the requirements of good laboratory practice are discussed.

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