Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Longitudinal changes in bone density in hyperparathyroidism.

G E Fuliehan1, F Moore, M S LeBoff

  • 1Endocrine-Hypertension Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. gf01@aub.edu.lb.

Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry
|September 28, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evidence-based multidisciplinary model of care for newborn screening in spinal muscular atrophy.

Genetics in medicine : official journal of the American College of Medical Genetics·2026
Same author

Exploring the Role of the Advanced Nurse Practitioner (ANP) Older Persons From the Perspective of the Interdisciplinary Team.

Journal of nursing management·2026
Same author

Comparative effectiveness and cost-effectiveness of natalizumab and fingolimod in rapidly evolving severe relapsing-remitting multiple sclerosis in the United Kingdom.

Journal of medical economics·2023
Same author

Pyrocumulonimbus affect average stratospheric aerosol composition.

Science (New York, N.Y.)·2023
Same author

Characterising recovery following abdominal aortic aneurysm repair using cardiopulmonary exercise testing and patient reported outcome measures.

Disability and rehabilitation·2022
Same author

Reducing Implant Infection in Orthopaedics (RIIiO): Results of a pilot study comparing the influence of forced air and resistive fabric warming technologies on postoperative infections following orthopaedic implant surgery.

The Journal of hospital infection·2019
Same journal

Comparison of adenoma and gland hyperplasia on bone mineral density in primary hyperparathyroidism.

Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry·2026
Same journal

The influence of pregnancy and selected aspects of female health on skeletal status and fracture incidence in postmenopausal women from the RACOST-POL Study.

Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry·2026
Same journal

The association of sclerostin with osteoporosis and vertebral fractures in patients with type 2 diabetes mellitus.

Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry·2026
Same journal

Assessment of bone microarchitecture in postmenopausal women with primary hyperparathyroidism using trabecular bone score.

Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry·2026
Same journal

Erxian decoction for postmenopausal osteoporosis: An updated systematic review and meta-analysis.

Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry·2026
Same journal

Associations of discordance in hip bone mineral density with hip osteoarthrosis severity and progression to total hip replacement in middle-aged adults.

Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry·2026
See all related articles

Parathyroidectomy (PAX) significantly increases bone mass in primary hyperparathyroidism (HPTH) patients within one year. Estrogen therapy combined with surgery may offer superior bone density improvements in postmenopausal women.

Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Surgical Outcomes

Background:

  • Primary hyperparathyroidism (HPTH) is a recognized risk factor for cortical bone loss.
  • Understanding bone mass changes post-parathyroidectomy (PAX) is crucial for managing HPTH.
  • The role of estrogen therapy in conjunction with PAX for bone health in postmenopausal women requires further investigation.

Purpose of the Study:

  • To investigate the temporal and spatial changes in bone mass during the first year following parathyroidectomy (PAX) in patients with primary hyperparathyroidism (HPTH).
  • To assess the efficacy of combined estrogen therapy and parathyroidectomy in improving bone density in postmenopausal women with HPTH.

Main Methods:

  • A prospective, longitudinal study involving 32 subjects with primary HPTH.

Related Experiment Videos

  • 27 subjects underwent parathyroidectomy (PTX); 5 served as controls.
  • Serial measurements of parathyroid hormone, serum chemistries, and bone density at multiple sites were conducted over at least one year.

    • Main Results:

    • All PTX patients showed significant increases in lumbar spine, hip, and whole-body bone mineral content (3.8-6%) by 12 months, with most gains by 3 months.
    • Postmenopausal women receiving estrogen alongside PTX exhibited potentially higher bone density increments at the femoral neck (8.6% vs. 4.9%) and whole body (6% vs. 2.4%) compared to those without estrogen.
    • These trends suggest a possible benefit of combined estrogen and PTX therapy, though statistical significance was borderline (p=0.07).

    Conclusions:

    • Early and generalized bone mass increments are observed following parathyroidectomy in HPTH patients.
    • Combined parathyroidectomy and estrogen therapy may offer superior bone density improvements in postmenopausal women compared to surgery alone.
    • A randomized controlled trial is recommended to definitively determine the optimal therapeutic strategy for postmenopausal women with HPTH.