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Positive selection of thymocytes: the long and winding road
G Anderson1, K J Hare, E J Jenkinson
1Dept of Anatomy, MRC Centre for Immune Regulation, Division of Infection and Immunity, The Medical School, University of Birmingham, Edgbaston, Birmingham, UK B15 2TT. andersog@novell2.bham.ac.uk
Immunology Today
|September 29, 1999
Abstract:
Positive selection is a crucial stage in T-cell development because it is here that CD4+CD8+ cells bearing T-cell receptors that interact with self-major histocompatibility complex molecules are rescued from cell death, resulting in the generation of mature T cells. Here, Graham Anderson and colleagues review recent studies indicating that positive selection is a multistage process involving interactions with thymic epithelium.