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Related Experiment Videos

Molecular analysis of developmental plasticity in neocortex.

E Nedivi1

  • 1Department of Brain and Cognitive Sciences, Center for Learning and Memory, Massachusetts Institute of Technology, 45 Carleton St., E25-435, Cambridge, Massachusetts 02139, USA.

Journal of Neurobiology
|September 30, 1999
PubMed
Summary

Activity-dependent plasticity in the visual cortex involves N-methyl-D-aspartate receptor activation, leading to gene expression changes. The role of specific plasticity genes can differ across various forms of neural plasticity.

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Activity-dependent plasticity is crucial for visual cortex development.
  • N-methyl-D-aspartate receptor activation influences gene expression related to plasticity.

Purpose of the Study:

  • To identify and characterize plasticity genes involved in activity-dependent developmental plasticity.
  • To understand the molecular mechanisms underlying ocular dominance plasticity.

Main Methods:

  • Gene expression studies.
  • Analysis of knockout mice with specific gene deletions.
  • Forward genetic screens.

Main Results:

  • N-methyl-D-aspartate receptor activation increases transcription factors and downstream targets.

Related Experiment Videos

  • The importance of plasticity genes varies depending on the context of expression.
  • Mutant mouse studies reveal plasticity is not a unified phenomenon.

    • Conclusions:

    • Identifying plasticity genes aids in dissecting molecular mechanisms.
    • Candidate genes from second-messenger pathways and transmission machinery are being investigated.
    • New candidate genes with defined cellular functions offer insights into plasticity mechanisms.