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Updated: Jul 10, 2026

Induction and Testing of Hypoxia in Cell Culture
Published on: August 12, 2011
Mechanisms of chronic hypoxia-induced renal cell growth
1Division of Nephrology and Hypertension, Northwestern University Medical School, Chicago, Illinois 60611-3010, USA. a-sahai@nwu.edu
Abstract:
Chronic local tissue hypoxia appears to play an important role in the initiation and progression of chronic renal disease. We examined the effect of local hypoxia on cultured renal tubular epithelial and mesangial cell proliferation, dedifferentiation, and extracellular matrix synthesis. The underlying signaling mechanisms whereby hypoxia induces renal cell growth were evaluated. The roles of protein kinase C, p38 mitogen-activated protein kinase, TGF-beta1, osteopontin, and nitric oxide were determined.
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