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Melanotic peritoneal sarcomatosis originating from clear cell sarcoma
1Laboratory of Molecular and Cellular Pathology, Hokkaido University School of Medicine, Sapporo, Japan.
Pathology International
|October 3, 1999
Summary
This study reports the first case of clear cell sarcoma (CCS) metastasizing to the peritoneum. The peritoneal tumors were diagnosed as CCS, originating from a prior wrist sarcoma.
Area of Science:
- Oncology
- Pathology
- Surgical Oncology
Background:
- Clear cell sarcoma (CCS) is a rare soft tissue sarcoma.
- Metastasis of CCS to the peritoneum is an uncommon presentation.
Observation:
- A 53-year-old male presented with peritoneal sarcomatosis.
- He had a history of clear cell sarcoma (CCS) of the right wrist resected 7 years prior.
Findings:
- Both the primary wrist tumor and peritoneal lesions showed small, spindle-shaped cells with occasional melanophages.
- Histologic, histochemical (argentaffin granules), immunohistochemical (HMB-45), and molecular (EWS-ATF-1 transcript) analyses confirmed CCS in peritoneal tumors.
- This represents the first documented case of peritoneal sarcomatosis associated with clear cell sarcoma.
Implications:
- This case expands the known metastatic patterns of clear cell sarcoma.
- Highlights the importance of considering rare metastatic sites in patients with a history of CCS.
- Suggests the need for vigilance in long-term surveillance for patients treated for CCS.