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Related Experiment Videos

Diffuse large B cell lymphoma expressing the natural killer cell marker CD56.

T Sekita1, J I Tamaru, K Isobe

  • 1First Department of Pathology, School of Medicine, Chiba University, Japan.

Pathology International
|October 3, 1999
PubMed
Summary

This study reports the first clear case of diffuse large B cell lymphoma (DLBL) expressing the natural killer (NK) cell antigen CD56. This rare finding in a common B-cell lymphoma offers new insights into DLBL heterogeneity.

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Area of Science:

  • Hematology
  • Immunology
  • Oncology

Background:

  • The natural killer (NK) cell antigen CD56 is rarely expressed in hematological malignancies.
  • While CD56 expression is reported in some T/NK cell lymphomas, multiple myeloma, and acute myeloid leukemia, its presence in B-cell non-Hodgkin's lymphomas (B-NHL) is exceptionally uncommon.
  • Previous reports on CD56 in B-NHL are limited, with only one study noting weak expression in diffuse large B cell lymphoma (DLBL).

Observation:

  • This report details the first documented case of DLBL with clear CD56 expression.
  • Immunophenotypic analysis revealed the tumor cells as CD10+, CD19+, CD20+, CD45RO-, CD3-, and CD56+.
  • Immunohistochemical studies showed no positivity for bcl-2 or TIA-1 in the tumor cells.

Findings:

  • The tumor exhibited monoclonal immunoglobulin heavy chain (IgH) gene rearrangement.

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  • Sequence analysis of the IgH variable region suggested the tumor originated from an antigen-selected, post-germinal center B cell.
  • The patient received conventional CHOP chemotherapy and achieved a complete remission lasting 10 months.

    • Implications:

    • This case expands the known immunophenotypic spectrum of DLBL.
    • The clear CD56 expression in this common B-NHL subtype warrants further investigation into its diagnostic and prognostic significance.
    • Understanding CD56 expression in DLBL may contribute to refining classification and therapeutic strategies for hematological malignancies.